This article is an effort to examine socio-political and economic impact of COVID-19 to state system global politics. Further, this study analyzes the response of US, China, Russia, India and Pakistan to Covid-19. Starting in December of 2019, first suspected as a mild cold in a seafood merchant of Hua'nan market was proved to be a fine example of "Butterfly" or you may call it "Domino" effect. At first it was taken by the world community an epidemic later regarded as a global pandemic engulfing over million of earthlings in matter of days, responsible for seizing its originating country and crippling the world's economy. As of 26 March 2020, the number of confirmed cases in the country is 1,179, with 21 recoveries and 9 deaths. World Health Organization has appreciated Pakistan for taking meaningful and timely steps deal with Corona Virus. The efforts to deal with Covid-19 by states with the help of World Health organization (WHO) are admirable. WHO is urging all countries to prepare for the potential arrival of COVID-19 by readying emergency response systems; increasing capacity to detect and care for patients; ensuring hospitals have the space, supplies and necessary personnel; and developing life-saving medical interventions. States in their own operational capacity are working around; Preparedness & Response, Containment and Mitigation.