Based on the Copenhagen school of thought, the securitization theory is applied to examine the framing of the Iranian nuclear deal as a security threat to the United States (US). The paper examines the transition from the Joint Comprehensive Plan of Action (JCPOA) to the Maximum Pressure Campaign under the Trump administration and the subsequent re-engagement efforts by the Biden administration. The research utilizes the theoretical framework of securitization to understand the securitizing actors, referent subjects, referent objects, audience, and context involved in the securitization process of the Iran nuclear deal. The paper also explores the implications of US foreign policy towards Iran's nuclear program for global nuclear non-proliferation efforts and its wider impact on US foreign policy in the Middle East. The findings contribute to a better understanding of the complexities and challenges of US foreign policy towards Iran's nuclear program, which is a key issue in international relations and nuclear non-proliferation efforts.